Semaglutide has become a widely discussed medication, particularly in the areas of weight management and type 2 diabetes treatment. It works by mimicking a hormone in the body called GLP-1 (glucagon-like peptide-1), which helps regulate blood sugar levels and reduces appetite, leading to weight loss. While it has shown promising results for many patients, it’s also important to understand the potential side effects of semaglutide, including whether it can make you feel tired.

In this article, we’ll explore whether semaglutide makes you tired, how common this side effect is, and what you can do to manage fatigue while taking the medication.

What is Semaglutide?

Semaglutide is a GLP-1 receptor agonist, a class of drugs that work by increasing insulin production, slowing down gastric emptying, and reducing appetite. This makes it particularly useful for people with type 2 diabetes and those looking to lose weight. It helps regulate blood sugar levels and can lead to significant weight loss by reducing hunger and promoting feelings of fullness.

While semaglutide has been a game-changer for many, like all medications, it comes with potential side effects. These side effects vary from person to person and can range from mild to more significant symptoms, including gastrointestinal issues, headaches, and fatigue.

Does Semaglutide Make You Tired?

One of the questions many people ask when considering semaglutide or after starting the medication is: Does semaglutide make you tired? Fatigue is a possible side effect, though it is not one of the most commonly reported symptoms. That said, some individuals may experience varying levels of tiredness while taking semaglutide.

There are a few reasons why fatigue might occur while on semaglutide, including how the medication interacts with your body and other underlying factors that might be contributing to the tiredness. Let’s break down some of the potential causes.

Why Might Semaglutide Cause Fatigue?

1. Changes in Blood Sugar Levels

Since semaglutide helps manage blood sugar by stimulating insulin production and slowing the release of glucose from the liver, some individuals may experience fluctuations in their blood sugar levels, especially in the early stages of treatment. Rapid changes in blood sugar can lead to feelings of fatigue, dizziness, or weakness. For people with type 2 diabetes, sudden drops in blood sugar (hypoglycemia) can be particularly exhausting and may contribute to tiredness while adjusting to the medication.

2. Decreased Calorie Intake

Semaglutide is known for its appetite-suppressing effects, which often lead to reduced calorie intake. While this is beneficial for weight loss, it can sometimes result in lower energy levels, especially if you’re not consuming enough nutrients to support your body’s needs. If your body is adjusting to a lower-calorie diet, you might experience temporary fatigue as your metabolism adapts to the changes.

3. Gastrointestinal Side Effects

Another potential contributor to feeling tired on semaglutide is its common gastrointestinal side effects. Nausea, vomiting, diarrhea, and constipation are among the more frequently reported issues when taking semaglutide. These side effects can lead to dehydration, which may leave you feeling fatigued or drained. Additionally, persistent nausea or stomach discomfort can disrupt your sleep patterns, further contributing to tiredness.

4. Adaptation to the Medication

As with many medications, your body may need time to adjust to semaglutide. During the first few weeks of treatment, it’s not uncommon to experience a range of mild side effects, including fatigue. Once your body gets used to the medication and your blood sugar levels stabilize, these side effects often subside.

Managing Fatigue While Taking Semaglutide

If you’re experiencing tiredness while taking semaglutide, there are steps you can take to minimize the impact and boost your energy levels:

1. Monitor Your Blood Sugar Levels

If you have diabetes and are taking semaglutide to manage your blood sugar, it’s important to keep a close eye on your glucose levels, especially during the early stages of treatment. Make sure you’re following your doctor’s recommendations for managing your blood sugar, and reach out if you notice any extreme fluctuations that could be contributing to your fatigue.

2. Adjust Your Diet

While semaglutide may reduce your appetite, it’s essential to maintain a balanced diet to support your body’s energy needs. Focus on consuming nutrient-dense foods that provide sustained energy throughout the day. Incorporating lean proteins, healthy fats, and complex carbohydrates can help stabilize your blood sugar levels and provide a consistent source of energy.

It’s also important to stay hydrated, especially if you’re experiencing any gastrointestinal side effects. Dehydration can lead to fatigue, so make sure you’re drinking plenty of water throughout the day.

3. Get Adequate Rest

Fatigue can often be managed by ensuring you’re getting enough sleep. If semaglutide is causing discomfort or other side effects that interfere with your sleep, talk to your healthcare provider about possible adjustments to your dosage or other remedies to improve your rest. Establishing a regular sleep routine can also help your body adjust to the medication and reduce feelings of tiredness during the day.

4. Exercise Regularly

While it might seem counterintuitive, regular physical activity can help boost your energy levels and combat fatigue. Engaging in moderate exercise, such as walking, swimming, or yoga, can improve circulation, enhance mood, and increase stamina. Even a short daily walk can make a big difference in how you feel over time.

If you’re feeling too fatigued to exercise, start with small, manageable activities and gradually build up your stamina.

5. Consult Your Healthcare Provider

If the tiredness persists or becomes overwhelming, it’s important to talk to your healthcare provider. They can help determine whether the fatigue is related to semaglutide or if there might be other factors at play. In some cases, adjusting the dosage or switching to a different medication may alleviate the issue. Your healthcare provider can also suggest additional strategies for managing side effects and ensuring you’re getting the most benefit from the medication.

While semaglutide is highly effective for managing type 2 diabetes and aiding in weight loss, some individuals may experience fatigue as a side effect. Although tiredness is not one of the most common side effects, fluctuations in blood sugar, decreased calorie intake, and gastrointestinal issues could all contribute to feelings of fatigue while on the medication.

Fortunately, there are ways to manage fatigue, from adjusting your diet to improving your sleep habits and incorporating regular exercise. If you’re concerned about feeling tired while taking semaglutide, consult your healthcare provider for personalized advice and guidance.

This article was written by Buffalo Weight Loss, Which has one of the most effective weight loss doctors in Buffalo, NY, for patients who are struggling with obesity. Semaglutide works by suppressing appetite and decreasing food intake, leading to weight loss.

The patient will be evaluated to determine the specific weight-loss needs and goals. BWL will receive a personalized treatment plan that includes Semaglutide in their weight loss program.

It works by mimicking the effects of a hormone called GLP-1, which regulates appetite and glucose metabolism. By activating GLP-1 receptors, Semaglutide reduces hunger and helps you feel full, leading to decreased calorie intake.